TITANIUM NANOPARTICLES CONJUGATED WITH STREPTOKINASE AS A MODIFIED THROMBOLYTIC AGENT
نویسندگان
چکیده
منابع مشابه
Streptokinase--a clinically useful thrombolytic agent.
A failure of hemostasis and consequent formation of blood clots in the circulatory system can produce severe outcomes such as stroke and myocardial infraction. Pathological development of blood clots requires clinical intervention with fibrinolytic agents such as urokinase, tissue plasminogen activator and streptokinase. This review deals with streptokinase as a clinically important and cost-ef...
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BACKGROUND Plasmin is capable of degrading extracellular matrix components such as collagen in vitro. To evaluate the significance of this for in vivo conditions, we set out to study the effect of streptokinase, which acts by converting plasminogen to plasmin, on the serum concentrations of the amino-terminal propeptide of type III procollagen (PIIINP) and the carboxy-terminal propeptide of typ...
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متن کاملThrombolytic therapy with streptokinase using a standard dosage.
The term " thrombolytic therapy " refers to the attempted removal of preformed intravascular fibrin occlusions using fibrinolytic agents. Several substances have been described as inducing a fibrinolytic state in the peripheral blood ; however, for only a few of these (namely, the plasminogen activators streptokinase and urokinase) was it proved beyond reasonable doubt that administration resul...
متن کاملMolecular processes in the streptokinase thrombolytic therapy.
The aim of this research is to evaluate the current streptokinase thrombolytic treatment and to identify or improve new techniques that will base new approaches with a higher efficiency in this area of expertise. In order to be as realistic as possible a new method was set up using magnetic vectorized nanoparticles streptokinase and human blood thrombus. The experimental data confirm the maximu...
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ژورنال
عنوان ژورنال: International Journal of Current Pharmaceutical Research
سال: 2020
ISSN: 0975-7066
DOI: 10.22159/ijcpr.2020v12i1.36824